GentShot (Penile PRP)

GentShot is GentsMed's brand name for penile platelet-rich plasma (PRP) — a regenerative-medicine procedure clinically referred to as intracavernosal PRP. PRP is prepared from the patient's own blood and injected into the penis. It is used for erectile function and sexual sensitivity, and sits in the broader regenerative-medicine landscape alongside shockwave therapy and stem-cell approaches. You may have heard it called the "P-Shot" elsewhere — it is the same category of procedure.

How it works

Blood is drawn (typically 30–60 mL), centrifuged to separate and concentrate platelets, and the resulting PRP is injected into the corpora cavernosa and glans after a local field block. The theory: platelets release growth factors (PDGF, VEGF, TGF-β, EGF) that stimulate tissue regeneration, angiogenesis, and neural recovery. The clinical effect, if any, develops over weeks as those biological processes unfold.

What the evidence supports — and does not

The evidence base is thin and uneven.¹ Small observational studies and case series report improvements in International Index of Erectile Function (IIEF) scores and subjective sensitivity.² Randomized placebo-controlled trials are sparse, and the International Society for Sexual Medicine has issued cautious guidance noting that PRP for ED remains investigational.³ Honest expectations are essential.

Who it is for

Most appropriate for men with mild-to-moderate ED who have not fully responded to PDE5 inhibitors, who want to avoid pharmaceutical dependence, or who are exploring options before escalating to intracavernosal injections. It is not a substitute for established treatments in moderate-to-severe vasculogenic ED.

What to expect

• In-office procedure, ~30–45 minutes total.
• Topical numbing + local field block. Most men report mild discomfort during injection.
• Minimal downtime — back to normal activity same day; avoid intense exercise for 24–48 hours.
• Effects, when present, develop over 4–8 weeks. Repeat treatments may be recommended.