Testosterone Therapy· Medication / Therapy
Kyzatrex
- Oral
- Twice-daily
- FDA-approved
Kyzatrex is an FDA-approved oral testosterone capsule. Taken twice daily with food, it delivers physiological testosterone replacement without injections. For men with confirmed low testosterone who prefer an oral protocol over weekly cypionate, Kyzatrex is the most-prescribed oral option in current US practice.
Typically used for:
Restoring testosterone in men with confirmed low T who prefer an oral protocol over injections.
Benefits
What Kyzatrex can do for you.
Energy + drive
Twice-daily oral dosing maintains steady serum testosterone, with most men reporting energy improvements in the first 6–8 weeks.
Libido + sexual function
Like other TRT formulations, Kyzatrex can improve libido and sexual function when low T is confirmed.
No needles
Oral capsule format eliminates self-injection — a meaningful difference for men who would otherwise avoid TRT.
Kyzatrex is an oral testosterone undecanoate capsule, FDA-approved in 2022.3 It joins JATENZO and Tlando as alternatives to injection-based TRT for men with confirmed hypogonadism.2 Twice-daily dosing with food restores serum testosterone to the physiological range in most appropriately selected patients.1
How it works
Oral testosterone has historically been limited by first-pass hepatic metabolism and hepatotoxicity. Kyzatrex sidesteps both: testosterone undecanoate is absorbed via the lymphatic system, bypassing the liver entirely on first pass.1 Serum testosterone peaks within 4–6 hours of each dose; consistent twice-daily dosing produces stable steady-state levels.
Who it is for
Symptomatic men with biochemically confirmed low testosterone who prefer an oral medication over injections. Particularly suited for needle-averse patients, frequent travelers, and men who want predictable daily dosing without the peak/trough swings of weekly cypionate.
What to expect
Energy, libido, and mood improvements are typically observed within 3–6 weeks. Body composition changes track over 3–6 months. Baseline and follow-up labs mirror standard TRT protocols: total testosterone, hematocrit, lipids, PSA, and estradiol at 6 weeks, 3 months, and then quarterly.
Important considerations
- Must be taken with food (specifically a meal with some fat) for proper absorption.
- Same fertility, hematocrit, and prostate-monitoring considerations apply as with all forms of TRT.
- Blood-pressure increases have been reported on Kyzatrex; baseline and follow-up BP monitoring is part of the standard protocol.
- More expensive than generic injectable cypionate; insurance coverage varies.
How it works
From consult to follow-up.
Initial consultation
A board-certified physician reviews your symptoms, history, and goals. At many participating clinics the first visit is complimentary.
Baseline labs
Bloodwork tailored to the protocol. Results come back in days, not weeks. We don't prescribe before we have your numbers.
Personalized protocol
Your physician calibrates your dose based on your labs and your goals — not a template. Adjustments happen as your data evolves.
Ongoing follow-up
Recheck visits at six and twelve weeks, then quarterly. Real follow-up, structured into the plan.
- Duration
- Twice-daily oral capsule with food
- Results timeline
- Energy and libido at 3–6 weeks; body composition over 3–6 months
Designed around your schedule
Consults are short
Initial visits are typically 45–60 minutes. Many participating clinics waive the fee for new patients.
Telehealth follow-ups
Where state regulations allow, follow-up visits are conducted via telehealth — no extra drive time.
Medication shipped
Prescriptions ship directly from a 503B-licensed pharmacy to your door. No standing in line.
Quarterly check-ins
Real follow-up at six and twelve weeks, then quarterly. Not constant visits, not zero visits.
Pricing
Kyzatrex, priced honestly.
Both tiers include medication and provider access. Comprehensive adds quarterly lab work and dose titration based on your real numbers — recommended for anyone serious about getting this right.
Essentials (Sample)
Twice-daily oral capsules
- Kyzatrex prescription (30-day supply)
- Initial telehealth consult
- 4-week lab review
- Standard shipping
Comprehensive (Sample)
Most popularOral T + labs + quarterly visits
- Everything in Essentials
- Quarterly full hormone panel
- Dose titration based on labs
- Portal access to your physician
Financing
Financing available through CareCredit at participating clinics.
Network providers
34 certified physicians offer Kyzatrex.
Every provider in the network is board-certified and credentialed.
Brandon Crandall, NP
Men's Health / Erectile Dysfunction · Syracuse, NY
Candace Remington, NP
Men's Health / Erectile Dysfunction · Tampa, FL
Deb Gross, NP
Men's Health / Erectile Dysfunction · Centralia, WA
Dr. Adriana Rosales, MD
Men's Health / Erectile Dysfunction · Seattle, WA
Dr. Aleix Bazzi, MD
Men's Health / Erectile Dysfunction · Beverly Hills, CA
Dr. Amit Grover, MD
Men's Health / Erectile Dysfunction · Seattle, WA
Dr. Ashish Bhavsar, MD
Men's Health / Erectile Dysfunction · Orange County, CA
Dr. Bona Lee, MD
Men's Health / Erectile Dysfunction · Dallas, TX
Dr. Brad Sellers, DO
Men's Health / Erectile Dysfunction · Dallas, TX
Patient reviews — Kyzatrex
★★★★☆4.0from 1 review
Eric M.
★★★★☆Tampa, FL · Sep 2024
Oral TRT has been a much better fit for me than injections. Twice-daily dose with food, labs at 4 weeks, then steady-state. No needles, no peaks-and-valleys.
Source: Internal Sample · Verified
Where to get it
Available in 23 cities.
Pick your metro to see the local clinics, providers, and booking options.
- Beverly Hills, CA2 clinics2 providers
- Dallas, TX2 clinics4 providers
- New York, NY2 clinics2 providers
- Orange County, CA2 clinics2 providers
- Syracuse, NY2 clinics2 providers
- Tampa, FL2 clinics3 providers
- Albany, NY1 clinic1 provider
- Albuquerque, NM1 clinic1 provider
- Boca Raton, FL1 clinic2 providers
- Burlington, ON1 clinic1 provider
- Centralia, WA1 clinic1 provider
- Cleveland, OH1 clinic1 provider
How they compare
Testosterone Cypionate vs Kyzatrex (oral T)
KyzatrexOral testosterone undecanoate · brand only | ||
|---|---|---|
| Route | Injection (IM or SubQ) | Oral capsule, twice daily with food |
| Dose frequency | Weekly or twice-weekly | Twice daily |
| Blood level pattern | Peak ~48 hrs post-injection, trough by day 7 | More stable steady-state with twice-daily dosing |
| Food requirement | None | Must be taken with meals — fat increases absorption |
| Hepatic safety | Bypasses first-pass liver metabolism | Safe in modern formulations; older oral methylated T was liver-toxic |
| Fertility preservation | Often requires HCG adjunct | Similar — suppresses LH/FSH like all exogenous T |
| Cost | Generic — ~$30–80/month at compounding pharmacies | ~$150–300/month (brand only) |
| Best for | Needle-tolerant patients who prefer the cost + protocol flexibility | Patients who refuse injections; those traveling frequently |
What sets us apart
Real physicians. Real labs. Real follow-up.
GentsMed is a network of board-certified physicians held to a single clinical standard — built to replace the cash-pay men's-health mills with actual medicine.
- Board-certified physicians.
- Every provider is licensed, NPI-verified, and credentialed by the GentsMed or Urosculpt certification board — no nurse-only prescribers, no offshore consults.
- A single clinical standard.
- Whether you see a urologist in Tampa or a dermatologist in New York, the protocol meets the same criteria.
- Labs-driven, not guess-driven.
- No prescriptions without baseline labs. No cookie-cutter dosing. Quarterly bloodwork is built into the plan.
- Real follow-up.
- Not a 'set it and forget it' Rx mill. Every protocol includes structured follow-up at 6 and 12 weeks, then quarterly.
- Transparent pricing.
- Starting-from prices where we have them, honest "consult for pricing" where we don't. No surprise bills.
- Your records stay with your physician.
- GentsMed is the network. We do not store your PHI. Your clinical data lives with your treating physician, where it belongs.
Frequently asked questions
References
- Swerdloff RS, et al. A New Oral Testosterone Undecanoate Formulation Restores Testosterone to Normal Concentrations in Hypogonadal Men. J Clin Endocrinol Metab. 2020;105(8):2515–2531.(PubMed)
- Mulhall JP, et al. AUA Guideline: Testosterone Deficiency. 2018.(AUA)
- FDA label: KYZATREX (testosterone undecanoate) capsules.(FDA)
Get started
Talk to a physician about Kyzatrex.
Every provider in the network is board-certified and credentialed. Find one near you in under a minute.