Question 1

Is Trimix safer than GentShot (Penile PRP)?

Accepted Answer

Different question. Trimix is more reliably effective — it works in >90% of men when properly dosed, including in severe vasculogenic and post-prostatectomy ED where PDE5 inhibitors and PRP both fail. GentShot is a different tool aimed at a different problem (improving baseline tissue function vs. producing an erection on demand). In terms of safety, both are physician-administered injection procedures with low complication rates when done correctly. Trimix's main risk is priapism if the dose is too high — which is why initial titration happens in clinic.

Question 2

How do I learn to inject Trimix?

Accepted Answer

In-clinic training. Your provider walks you through the technique once or twice — site selection, needle insertion angle, depth, and post-injection compression. Most men feel comfortable self-injecting after 1–2 supervised sessions. The needles are very fine (typically 30-gauge) and the discomfort is minimal once you get past the psychological barrier. Many patients describe it as easier than they expected.

Question 3

What if I get a priapism?

Accepted Answer

Any erection lasting more than 4 hours after a Trimix injection requires emergency-room evaluation. Untreated priapism can cause permanent tissue damage and lead to chronic ED — the very condition you're trying to treat. Risk is highest during initial dose titration. Your provider will start at a low dose and adjust upward, and you should know what signs to watch for. If it happens, go to the ER — they have protocols (aspiration, phenylephrine injection) that resolve it quickly.

Question 4

How long does a Trimix erection last?

Accepted Answer

Properly dosed, 30–90 minutes — the goal is "lasts as long as needed for the sexual encounter, then resolves." If you find your erection lasting longer than 2 hours consistently, the dose is too high and needs to be reduced.

Question 5

Will my insurance cover Trimix?

Accepted Answer

Usually not — Trimix is compounded (not FDA-approved as a combination product), so insurance coverage is rare. Cash-pay pricing varies by pharmacy but is generally a few hundred dollars per multi-dose vial. If individual components (e.g., alprostadil as Caverject) are covered, that may be an option, though most men find the combined Trimix more cost-effective than separate components.

Trimix in Cleveland, OH

Benefits

Works when oral fails

Reliable on-demand

Adjustable dosing

How it works

Initial consultation

Baseline labs

Personalized protocol

Ongoing follow-up

Designed around your schedule

Cleveland clinics on the map

Where to get it

Upsize Cleveland

Provider offering this service

Patient reviews in Cleveland

What sets us apart

Talk to a Cleveland physician about trimix.